Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses

The precise signaling mechanisms by which type II IFN receptors control expression of unique genes to induce biological responses remain to be established. We provide evidence that Sin1, a known element of the mammalian target of rapamycin complex 2 (mTORC2), is required for IFNγ-induced phosphoryla...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Kroczynska, Barbara, Blyth, Gavin T., Rafidi, Robert L., Majchrzak-Kita, Beata, Xu, Lucy, Saleiro, Diana, Kosciuczuk, Ewa M., Jemielity, Jacek, Su, Bing, Altman, Jessica K., Eklund, Elizabeth A., Fish, Eleanor N., Platanias, Leonidas C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377787/
https://ncbi.nlm.nih.gov/pubmed/28174303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.757666
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