The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells

Self-renewing naïve mouse embryonic stem cells (mESCs) contain few mitochondria, which increase in number and volume at the onset of differentiation. KBP (encoded by Kif1bp) is an interactor of the mitochondrial-associated kinesin Kif1Bα. We found that TDH, responsible for mitochondrial production o...

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Vydáno v:Nat Cell Biol
Hlavní autoři: Donato, Valerio, Bonora, Massimo, Simoneschi, Daniele, Sartini, Davide, Kudo, Yasusei, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Stadtfeld, Matthias, Pinton, Paolo, Pagano, Michele
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376241/
https://ncbi.nlm.nih.gov/pubmed/28319092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3491
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