SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity via CP110 degradation

Generally, F-box proteins are the substrate recognition subunits of SCF (Skp1-Cul1-F-box protein) ubiquitin ligase complexes, which mediate the timely proteolysis of important eukaryotic regulatory proteins1,2. Mammalian genomes encode roughly 70 F-box proteins, but only a handful have established f...

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Huvudupphovsmän: D’Angiolella, Vincenzo, Donato, Valerio, Vijayakumar, Sangeetha, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Dynlacht, Brian, Pagano, Michele
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946399/
https://ncbi.nlm.nih.gov/pubmed/20596027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09140
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