Mitochondrial genome regulates mitotic fidelity by maintaining centrosomal homeostasis

Centrosomes direct spindle morphogenesis to assemble a bipolar mitotic apparatus to enable error-free chromosome segregation and preclude chromosomal instability (CIN). Amplified centrosomes, a hallmark of cancer cells, set the stage for CIN, which underlies malignant transformation and evolution of...

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Main Authors: Donthamsetty, Shashikiran, Brahmbhatt, Meera, Pannu, Vaishali, Rida, Padmashree CG, Ramarathinam, Sujatha, Ogden, Angela, Cheng, Alice, Singh, Keshav K, Aneja, Ritu
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111697/
https://ncbi.nlm.nih.gov/pubmed/24799670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.29061
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