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Mitochondrial genome regulates mitotic fidelity by maintaining centrosomal homeostasis
Centrosomes direct spindle morphogenesis to assemble a bipolar mitotic apparatus to enable error-free chromosome segregation and preclude chromosomal instability (CIN). Amplified centrosomes, a hallmark of cancer cells, set the stage for CIN, which underlies malignant transformation and evolution of...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4111697/ https://ncbi.nlm.nih.gov/pubmed/24799670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.29061 |
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