The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells

Self-renewing naïve mouse embryonic stem cells (mESCs) contain few mitochondria, which increase in number and volume at the onset of differentiation. KBP (encoded by Kif1bp) is an interactor of the mitochondrial-associated kinesin Kif1Bα. We found that TDH, responsible for mitochondrial production o...

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Publicado no:Nat Cell Biol
Main Authors: Donato, Valerio, Bonora, Massimo, Simoneschi, Daniele, Sartini, Davide, Kudo, Yasusei, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Stadtfeld, Matthias, Pinton, Paolo, Pagano, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376241/
https://ncbi.nlm.nih.gov/pubmed/28319092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3491
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