PTEN counteracts FBXL2 to promote IP3R3– and Ca(2+)–mediated apoptosis limiting tumour growth

In response to environmental cues that promote IP3 (inositol 1,4,5-trisphosphate) generation, IP3 receptors (IP3Rs) located on the endoplasmic reticulum allow the ‘quasisynaptical’ feeding of calcium to the mitochondria to promote oxidative phosphorylation(1). However, persistent Ca(2+) release resu...

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Pubblicato in:Nature
Autori principali: Kuchay, Shafi, Giorgi, Carlotta, Simoneschi, Daniele, Pagan, julia, Missiroli, Sonia, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Collazo-Lorduy, Ana, Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Sebti, Said M., Pinton, Paolo, Pagano, Michele
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627969/
https://ncbi.nlm.nih.gov/pubmed/28614300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22965
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