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Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB
Accumulating evidence highlights the role of histone acetyltransferase GCN5 in the regulation of cell metabolism in metazoans. Here, we report that GCN5 is a negative regulator of autophagy, a lysosome‐dependent catabolic mechanism. In animal cells and Drosophila, GCN5 inhibits the biogenesis of aut...
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| Publicado no: | EMBO Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6945067/ https://ncbi.nlm.nih.gov/pubmed/31750630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948335 |
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