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Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB
Accumulating evidence highlights the role of histone acetyltransferase GCN5 in the regulation of cell metabolism in metazoans. Here, we report that GCN5 is a negative regulator of autophagy, a lysosome‐dependent catabolic mechanism. In animal cells and Drosophila, GCN5 inhibits the biogenesis of aut...
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| Publicat a: | EMBO Rep |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley and Sons Inc.
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6945067/ https://ncbi.nlm.nih.gov/pubmed/31750630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948335 |
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