Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB

Accumulating evidence highlights the role of histone acetyltransferase GCN5 in the regulation of cell metabolism in metazoans. Here, we report that GCN5 is a negative regulator of autophagy, a lysosome‐dependent catabolic mechanism. In animal cells and Drosophila, GCN5 inhibits the biogenesis of aut...

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Bibliographic Details
Published in:EMBO Rep
Main Authors: Wang, Yusha, Huang, Yewei, Liu, Jiaqi, Zhang, Jinna, Xu, Mingming, You, Zhiyuan, Peng, Chao, Gong, Zhefeng, Liu, Wei
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6945067/
https://ncbi.nlm.nih.gov/pubmed/31750630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948335
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