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Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine
Ten-eleven translocation (TET) enzymes catalyze stepwise oxidation of 5-methylcytosine (mC) to yield 5-hydroxymethylcytosine (hmC) and the rarer bases 5-formylcytosine (fC) and 5-carboxylcytosine (caC). Stepwise oxidation obscures how each individual base forms and functions in epigenetic regulation...
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| Publicado no: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5370579/ https://ncbi.nlm.nih.gov/pubmed/27918559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2250 |
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