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Selectivity and Promiscuity in TET-mediated oxidation of 5-methylcytosine in DNA and RNA
Enzymes of the ten-eleven translocation (TET) family add diversity to the repertoire of nucleobase modifications by catalyzing the oxidation of 5-methylcytosine (5mC). TET enzymes were initially found to oxidize 5-methyl-2’-deoxycytidine in genomic DNA, yielding products that contribute to epigeneti...
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| Publié dans: | Biochemistry |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6363868/ https://ncbi.nlm.nih.gov/pubmed/30387995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00912 |
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