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Exploiting Substrate Promiscuity to Develop Activity-Based Probes for TET Family Enzymes
TET enzymes catalyze repeated oxidations of 5-methylcytosine in genomic DNA. Due to the challenges of track-ing reactivity within a complex DNA substrate, chemical tools to probe TET activity are limited, despite these enzyme’s crucial role in epigenetic regulation. Here, building on precedents from...
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| Publicado en: | J Am Chem Soc |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6470038/ https://ncbi.nlm.nih.gov/pubmed/30518204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b04722 |
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