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Exploiting Substrate Promiscuity to Develop Activity-Based Probes for TET Family Enzymes

TET enzymes catalyze repeated oxidations of 5-methylcytosine in genomic DNA. Due to the challenges of track-ing reactivity within a complex DNA substrate, chemical tools to probe TET activity are limited, despite these enzyme’s crucial role in epigenetic regulation. Here, building on precedents from...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Ghanty, Uday, DeNizio, Jamie E., Liu, Monica Yun, Kohli, Rahul M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470038/
https://ncbi.nlm.nih.gov/pubmed/30518204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b04722
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