Načítá se...
Insight into wild-type and T1372E TET2-mediated 5hmC oxidation using ab initio QM/MM calculations
Ten-eleven translocation 2 (TET2) is an Fe/α-ketoglutarate (α-KG) dependent enzyme that dealkylates 5-methylcytosine (5mC). The reaction mechanism involves a series of three sequential oxidations that convert 5mC to 5-hydroxy-methylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC...
Uloženo v:
| Vydáno v: | Chem Sci |
|---|---|
| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Royal Society of Chemistry
2018
|
| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6244454/ https://ncbi.nlm.nih.gov/pubmed/30542593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc02961j |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!
|