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Insight into wild-type and T1372E TET2-mediated 5hmC oxidation using ab initio QM/MM calculations

Ten-eleven translocation 2 (TET2) is an Fe/α-ketoglutarate (α-KG) dependent enzyme that dealkylates 5-methylcytosine (5mC). The reaction mechanism involves a series of three sequential oxidations that convert 5mC to 5-hydroxy-methylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Chem Sci
Hauptverfasser: Torabifard, Hedieh, Cisneros, G. Andrés
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6244454/
https://ncbi.nlm.nih.gov/pubmed/30542593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc02961j
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