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The challenges of tumor genetic diversity

We review and discuss the implications of genomic analyses documenting the diversity of tumors, both among patients and within individual tumors. Genetic diversity among solid tumors limits targeted therapies, as few mutations that drive tumors are both targetable and at high prevalence. Many more d...

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Dettagli Bibliografici
Pubblicato in:Cancer
Autori principali: Mroz, Edmund A., Rocco, James W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5370554/
https://ncbi.nlm.nih.gov/pubmed/27861749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30430
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