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High intra-tumor genetic heterogeneity is related to worse outcome in head and neck squamous cell carcinoma

BACKGROUND: Although the presence of genetic heterogeneity within individual patients’ tumors is established, it is unclear whether greater heterogeneity predicts worse outcome. A quantitative measure of genetic heterogeneity based on next-generation sequencing (NGS) data, mutant-allele tumor hetero...

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Bibliografiske detaljer
Main Authors: Mroz, Edmund A., Tward, Aaron D., Pickering, Curtis R., Myers, Jeffrey N., Ferris, Robert L., Rocco, James W.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735618/
https://ncbi.nlm.nih.gov/pubmed/23696076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.28150
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