Codon-level co-occurrences of germline variants and somatic mutations in cancer are rare but often lead to incorrect variant annotation and underestimated impact prediction

Cancer cells explore a broad mutational landscape, bringing the possibility that tumor-specific somatic mutations could fall in the same codons as germline SNVs and leverage their presence to produce substitutions with a larger impact on protein function. While multiple, temporally consecutive mutat...

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Vydáno v:PLoS One
Hlavní autoři: Koire, Amanda, Kim, Young Won, Wang, Jarey, Katsonis, Panagiotis, Jin, Haijing, Lichtarge, Olivier
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5370158/
https://ncbi.nlm.nih.gov/pubmed/28350864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174766
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