Glutamate-dependent ectodomain shedding of neuregulin-1 type II precursors in rat forebrain neurons

The neurotrophic factor neuregulin 1 (NRG1) regulates neuronal development, glial differentiation, and excitatory synapse maturation. NRG1 is synthesized as a membrane-anchored precursor and is then liberated by proteolytic processing or exocytosis. Mature NRG1 then binds to its receptors expressed...

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Vydáno v:PLoS One
Hlavní autoři: Iwakura, Yuriko, Wang, Ran, Inamura, Naoko, Araki, Kazuaki, Higashiyama, Shigeki, Takei, Nobuyuki, Nawa, Hiroyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5370147/
https://ncbi.nlm.nih.gov/pubmed/28350885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174780
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