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Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia: Their Target Cells and Time Window

Neuregulin-1 and epidermal growth factor (EGF) are implicated in the pathogenesis of schizophrenia. To test the developmental hypothesis for schizophrenia, we administered these factors to rodent pups, juveniles, and adults and characterized neurobiological and behavioral consequences. These factors...

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Detalhes bibliográficos
Main Authors: Hiroyuki Nawa, Hidekazu Sotoyama, Yuriko Iwakura, Nobuyuki Takei, Hisaaki Namba
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Limited 2014-01-01
Colecção:BioMed Research International
Acesso em linha:http://dx.doi.org/10.1155/2014/697935
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