ErbB2 Dephosphorylation and Anti-Proliferative Effects of Neuregulin-1 in ErbB2-Overexpressing Cells; Re-evaluation of Their Low-Affinity Interaction

Neuregulin-1 binds to ErbB3 and ErbB4 and regulates cancer proliferation and differentiation. Neuregulin-1 had been suggested to also react with ErbB2, but this argument becomes controversial. Here, we re-evaluated the cellular responses and ErbB2 interaction of neuregulin-1 in ErbB2 overexpressing...

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Main Authors: Wang, Ran, Iwakura, Yuriko, Araki, Kazuaki, Keino-Masu, Kazuko, Masu, Masayuki, Wang, Xue-yi, Takei, Nobuyuki, Higashiyama, Shigeki, Nawa, Hiroyuki
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590560/
https://ncbi.nlm.nih.gov/pubmed/23466678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01402
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