Prostaglandin E(2) Mediates Immunosuppression in Acutely Decompensated Cirrhosis

Patients with advanced cirrhosis experience frequent infections leading to sepsis, which carries high mortality. While innate immune dysfunction underlies this vulnerability, the precise cause remains elusive. We found prostaglandin (PGE(2)) elevated in acutely decompensated (AD) patients at immunos...

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Pubblicato in:Nat Med
Autori principali: O’Brien, Alastair J., Fullerton, James N., Massey, Karen A., Auld, Grace, Sewell, Gavin, James, Sarah, Newson, Justine, Karra, Effie, Winstanley, Alison, Alazawi, William, Garcia-Marquez, Rita, Cordoba, Juan, Nicolaou, Anna, Gilroy, Derek W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5369639/
https://ncbi.nlm.nih.gov/pubmed/24728410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3516
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