Bile duct‐ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences

BACKGROUND & AIMS: Patients with decompensated cirrhosis are susceptible to infection. Innate immune dysfunction and development of organ failure are considered to underlie this. A rodent model of liver disease sharing these phenotypic features would assist in vivo study of underlying mechanisms...

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Detalles Bibliográficos
Publicado en:Liver Int
Main Authors: O'Brien, Alastair, China, Louise, Massey, Karen A., Nicolaou, Anna, Winstanley, Alison, Newson, Justine, Hobbs, Adrian, Audzevich, Tatsiana, Gilroy, Derek W.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2015
Assuntos:
Cirrhosis and its Complications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869675/
https://ncbi.nlm.nih.gov/pubmed/26012885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/liv.12876
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