Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

Prostate cancer relapsing from antiandrogen therapies can exhibit variant histology with altered lineage marker expression, suggesting that lineage plasticity facilitates therapeutic resistance. The mechanisms underlying prostate cancer lineage plasticity are incompletely understood. Studying mouse...

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Foilsithe in:Science
Main Authors: Ku, Sheng Yu, Rosario, Spencer, Wang, Yanqing, Mu, Ping, Seshadri, Mukund, Goodrich, Zachary W., Goodrich, Maxwell M., Labbé, David P., Gomez, Eduardo Cortes, Wang, Jianmin, Long, Henry W., Xu, Bo, Brown, Myles, Loda, Massimo, Sawyers, Charles L., Ellis, Leigh, Goodrich, David W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367887/
https://ncbi.nlm.nih.gov/pubmed/28059767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aah4199
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