Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

Prostate cancer relapsing from antiandrogen therapies can exhibit variant histology with altered lineage marker expression, suggesting that lineage plasticity facilitates therapeutic resistance. The mechanisms underlying prostate cancer lineage plasticity are incompletely understood. Studying mouse...

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Vydáno v:Science
Hlavní autoři: Ku, Sheng Yu, Rosario, Spencer, Wang, Yanqing, Mu, Ping, Seshadri, Mukund, Goodrich, Zachary W., Goodrich, Maxwell M., Labbé, David P., Gomez, Eduardo Cortes, Wang, Jianmin, Long, Henry W., Xu, Bo, Brown, Myles, Loda, Massimo, Sawyers, Charles L., Ellis, Leigh, Goodrich, David W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367887/
https://ncbi.nlm.nih.gov/pubmed/28059767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aah4199
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