Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

Prostate cancer relapsing from antiandrogen therapies can exhibit variant histology with altered lineage marker expression, suggesting that lineage plasticity facilitates therapeutic resistance. The mechanisms underlying prostate cancer lineage plasticity are incompletely understood. Studying mouse...

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Publicado en:Science
Autores principales: Ku, Sheng Yu, Rosario, Spencer, Wang, Yanqing, Mu, Ping, Seshadri, Mukund, Goodrich, Zachary W., Goodrich, Maxwell M., Labbé, David P., Gomez, Eduardo Cortes, Wang, Jianmin, Long, Henry W., Xu, Bo, Brown, Myles, Loda, Massimo, Sawyers, Charles L., Ellis, Leigh, Goodrich, David W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367887/
https://ncbi.nlm.nih.gov/pubmed/28059767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aah4199
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