Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

Prostate cancer relapsing from antiandrogen therapies can exhibit variant histology with altered lineage marker expression, suggesting that lineage plasticity facilitates therapeutic resistance. The mechanisms underlying prostate cancer lineage plasticity are incompletely understood. Studying mouse...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Science
Prif Awduron: Ku, Sheng Yu, Rosario, Spencer, Wang, Yanqing, Mu, Ping, Seshadri, Mukund, Goodrich, Zachary W., Goodrich, Maxwell M., Labbé, David P., Gomez, Eduardo Cortes, Wang, Jianmin, Long, Henry W., Xu, Bo, Brown, Myles, Loda, Massimo, Sawyers, Charles L., Ellis, Leigh, Goodrich, David W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367887/
https://ncbi.nlm.nih.gov/pubmed/28059767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aah4199
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