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Methyl-orvinol – dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking IBS-D

BACKGROUND: Diarrhea-predominant irritable bowel syndrome (IBSD) is a functional disorder of the gastrointestinal (GI) tract. The major IBS-D symptoms include diarrhea, abdominal pain and discomfort. High density of opioid receptors (ORs) in the GI tract and their participation in the maintenance of...

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Bibliografiske detaljer
Udgivet i:Pharmacol Rep
Main Authors: Zielińska, Marta, Jarmuż, Agata, Wasilewski, Andrzej, Cami-Kobeci, Gerta, Husbands, Stephen, Fichna, Jakub
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367634/
https://ncbi.nlm.nih.gov/pubmed/28187396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharep.2016.12.001
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