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Methyl-orvinol – dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking IBS-D
BACKGROUND: Diarrhea-predominant irritable bowel syndrome (IBSD) is a functional disorder of the gastrointestinal (GI) tract. The major IBS-D symptoms include diarrhea, abdominal pain and discomfort. High density of opioid receptors (ORs) in the GI tract and their participation in the maintenance of...
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| Publicado no: | Pharmacol Rep |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5367634/ https://ncbi.nlm.nih.gov/pubmed/28187396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharep.2016.12.001 |
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