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Novel mixed NOP/MOP agonist BU08070 alleviates pain and inhibits gastrointestinal motility in mouse models mimicking diarrhea-predominant irritable bowel syndrome symptoms

BACKGROUND: The opioid and nociceptin systems play a crucial role in the maintenance of homeostasis in the gastrointestinal (GI) tract. The aim of this study was to characterize the effect of BU08070, a novel mixed MOP/NOP agonist, on mouse intestinal contractility in vitro and GI motility in vivo i...

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Detalhes bibliográficos
Publicado no:Eur J Pharmacol
Main Authors: Sobczak, Marta, Cami-Kobeci, Gerta, Sałaga, Maciej, Husbands, Stephen M., Fichna, Jakub
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4341819/
https://ncbi.nlm.nih.gov/pubmed/24815321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2014.04.038
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