Desensitization of transient receptor potential vanilloid type-1 (TRPV1) channel as promising therapy of irritable bowel syndrome: characterization of the action of palvanil in the mouse gastrointestinal tract

TRPV1 are involved in the control of the gastrointestinal (GI) functions and pain sensation. Their activation induces pain but it is followed by desensitization, which in turn causes analgesia. The studies from the last two decades indicate that TRPV1 are involved in visceral hypersensitivity in the...

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Detalhes bibliográficos
Publicado no:Naunyn Schmiedebergs Arch Pharmacol
Main Authors: Szymaszkiewicz, Agata, Włodarczyk, Jakub, Wasilewski, Andrzej, Di Marzo, Vincenzo, Storr, Martin, Fichna, Jakub, Zielińska, Marta
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351811/
https://ncbi.nlm.nih.gov/pubmed/32002574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00210-020-01829-x
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