A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates

Despite the critical need, no previous research has substantiated safe opioid analgesics without abuse liability in primates. Recent advances in medicinal chemistry have led to the development of ligands with mixed mu opioid peptide (MOP)/nociceptin-orphanin FQ peptide (NOP) receptor agonist activit...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ding, Huiping, Czoty, Paul W., Kiguchi, Norikazu, Cami-Kobeci, Gerta, Sukhtankar, Devki D., Nader, Michael A., Husbands, Stephen M., Ko, Mei-Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027459/
https://ncbi.nlm.nih.gov/pubmed/27573832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605295113
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