BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates

BACKGROUND: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have agonist action at both mu opioid peptide (MOP) and nociceptin/orphanin FQ peptide (NOP) receptors. BU10038 is a recently identified...

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Detalhes bibliográficos
Publicado no:Br J Anaesth
Main Authors: Kiguchi, Norikazu, Ding, Huiping, Cami-Kobeci, Gerta, Sukhtankar, Devki D., Czoty, Paul W., DeLoid, Heather B., Hsu, Fang-Chi, Toll, Lawrence, Husbands, Stephen M., Ko, Mei-Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676776/
https://ncbi.nlm.nih.gov/pubmed/30916003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2018.10.065
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