A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates

Despite the critical need, no previous research has substantiated safe opioid analgesics without abuse liability in primates. Recent advances in medicinal chemistry have led to the development of ligands with mixed mu opioid peptide (MOP)/nociceptin-orphanin FQ peptide (NOP) receptor agonist activit...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Ding, Huiping, Czoty, Paul W., Kiguchi, Norikazu, Cami-Kobeci, Gerta, Sukhtankar, Devki D., Nader, Michael A., Husbands, Stephen M., Ko, Mei-Chuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027459/
https://ncbi.nlm.nih.gov/pubmed/27573832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605295113
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