Inhibition of the β-Lactamase Bla(Mab) by Avibactam Improves the In Vitro and In Vivo Efficacy of Imipenem against Mycobacterium abscessus

Mycobacterium abscessus pulmonary infections are treated with a macrolide (clarithromycin or azithromycin), an aminoglycoside (amikacin), and a β-lactam (cefoxitin or imipenem). The triple combination is used without any β-lactamase inhibitor, even though M. abscessus produces the broad-spectrum β-l...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Lefebvre, Anne-Laure, Le Moigne, Vincent, Bernut, Audrey, Veckerlé, Carole, Compain, Fabrice, Herrmann, Jean-Louis, Kremer, Laurent, Arthur, Michel, Mainardi, Jean-Luc
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
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Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365697/
https://ncbi.nlm.nih.gov/pubmed/28096155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02440-16
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