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Impaired Inhibition by Avibactam and Resistance to the Ceftazidime-Avibactam Combination Due to the D(179)Y Substitution in the KPC-2 β-Lactamase
The ceftazidime-avibactam antibiotic combination was recently shown to be at risk for the emergence of resistance under treatment. To gain insight into the underlying mechanism, we have analyzed the catalytic properties of a Klebsiella pneumoniae carbapenemase type 2 (KPC-2) β-lactamase harboring th...
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| Publicado no: | Antimicrob Agents Chemother |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5487616/ https://ncbi.nlm.nih.gov/pubmed/28461318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00451-17 |
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