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Mutations in bla(KPC-3) That Confer Ceftazidime-Avibactam Resistance Encode Novel KPC-3 Variants That Function as Extended-Spectrum β-Lactamases
We identified four bla(KPC-3) mutations in ceftazidime-avibactam-resistant clinical Klebsiella pneumoniae isolates, corresponding to D179Y, T243M, D179Y/T243M, and EL165-166 KPC-3 variants. Using site-directed mutagenesis and transforming vectors into Escherichia coli, we conclusively demonstrated t...
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| Publié dans: | Antimicrob Agents Chemother |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5404534/ https://ncbi.nlm.nih.gov/pubmed/28223379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02534-16 |
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