Mutations in bla(KPC-3) That Confer Ceftazidime-Avibactam Resistance Encode Novel KPC-3 Variants That Function as Extended-Spectrum β-Lactamases

We identified four bla(KPC-3) mutations in ceftazidime-avibactam-resistant clinical Klebsiella pneumoniae isolates, corresponding to D179Y, T243M, D179Y/T243M, and EL165-166 KPC-3 variants. Using site-directed mutagenesis and transforming vectors into Escherichia coli, we conclusively demonstrated t...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Haidar, Ghady, Clancy, Cornelius J., Shields, Ryan K., Hao, Binghua, Cheng, Shaoji, Nguyen, M. Hong
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404534/
https://ncbi.nlm.nih.gov/pubmed/28223379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02534-16
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