KPC Beta-Lactamases Are Permissive to Insertions and Deletions Conferring Substrate Spectrum Modifications and Resistance to Ceftazidime-Avibactam

To explore the mutational possibilities of insertions and deletions (indels) in the Klebsiella pneumoniae carbapenemase (KPC) beta-lactamase, we selected for ceftazidime-avibactam-resistant mutants. Of 96 screened mutants, we obtained 19 indels (2 to 15 amino acids), all located in the loops surroun...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Hobson, Claire Amaris, Bonacorsi, Stéphane, Jacquier, Hervé, Choudhury, Alaksh, Magnan, Mélanie, Cointe, Aurélie, Bercot, Béatrice, Tenaillon, Olivier, Birgy, André
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2020
Assuntos:
Mechanisms of Resistance
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674030/
https://ncbi.nlm.nih.gov/pubmed/33020157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01175-20
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