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Impaired Inhibition by Avibactam and Resistance to the Ceftazidime-Avibactam Combination Due to the D(179)Y Substitution in the KPC-2 β-Lactamase

The ceftazidime-avibactam antibiotic combination was recently shown to be at risk for the emergence of resistance under treatment. To gain insight into the underlying mechanism, we have analyzed the catalytic properties of a Klebsiella pneumoniae carbapenemase type 2 (KPC-2) β-lactamase harboring th...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Compain, Fabrice, Arthur, Michel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487616/
https://ncbi.nlm.nih.gov/pubmed/28461318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00451-17
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