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Ceftazidime-Avibactam Resistance Mediated by the N(346)Y Substitution in Various AmpC β-Lactamases

Chromosomal and plasmid-borne AmpC cephalosporinases are a major resistance mechanism to β-lactams in Enterobacteriaceae and Pseudomonas aeruginosa. The new β-lactamase inhibitor avibactam effectively inhibits class C enzymes and can fully restore ceftazidime susceptibility. The conserved amino acid...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Compain, Fabrice, Debray, Agathe, Adjadj, Pauline, Dorchêne, Delphine, Arthur, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269493/
https://ncbi.nlm.nih.gov/pubmed/32253219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02311-19
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