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Ceftazidime-Avibactam Resistance Mediated by the N(346)Y Substitution in Various AmpC β-Lactamases
Chromosomal and plasmid-borne AmpC cephalosporinases are a major resistance mechanism to β-lactams in Enterobacteriaceae and Pseudomonas aeruginosa. The new β-lactamase inhibitor avibactam effectively inhibits class C enzymes and can fully restore ceftazidime susceptibility. The conserved amino acid...
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| Publié dans: | Antimicrob Agents Chemother |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7269493/ https://ncbi.nlm.nih.gov/pubmed/32253219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02311-19 |
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