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Combination of Amino Acid Substitutions Leading to CTX-M-15-Mediated Resistance to the Ceftazidime-Avibactam Combination

Single amino acid substitutions in the Ω loop of KPC β-lactamases are known to lead to resistance to the ceftazidime-avibactam combination. Here, we investigate this mechanism of resistance in CTX-M enzymes, which are the most widely spread extended-spectrum β-lactamases worldwide. Nine single amino...

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Bibliografski detalji
Izdano u:Antimicrob Agents Chemother
Glavni autori: Compain, Fabrice, Dorchène, Delphine, Arthur, Michel
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125495/
https://ncbi.nlm.nih.gov/pubmed/29941650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00357-18
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