Impact of β-Lactamase Inhibition on the Activity of Ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus

The production of β-lactamases Bla(Mab) and BlaC contributes to β-lactam resistance in Mycobacterium abscessus and Mycobacterium tuberculosis, respectively. Ceftaroline was efficiently hydrolyzed by these enzymes. Inhibition of M. tuberculosis BlaC by clavulanate decreased the ceftaroline MIC from ≥...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Dubée, Vincent, Soroka, Daria, Cortes, Mélanie, Lefebvre, Anne-Laure, Gutmann, Laurent, Hugonnet, Jean-Emmanuel, Arthur, Michel, Mainardi, Jean-Luc
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394810/
https://ncbi.nlm.nih.gov/pubmed/25733512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05080-14
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