Defining RNA–Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA

[Image: see text] RNA drug targets are pervasive in cells, but methods to design small molecules that target them are sparse. Herein, we report a general approach to score the affinity and selectivity of RNA motif–small molecule interactions identified via selection. Named High Throughput Structure–...

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Detalhes bibliográficos
Publicado no:ACS Cent Sci
Main Authors: Velagapudi, Sai Pradeep, Luo, Yiling, Tran, Tuan, Haniff, Hafeez S., Nakai, Yoshio, Fallahi, Mohammad, Martinez, Gustavo J., Childs-Disney, Jessica L., Disney, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364451/
https://ncbi.nlm.nih.gov/pubmed/28386598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.7b00009
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