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Defining RNA–Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA
[Image: see text] RNA drug targets are pervasive in cells, but methods to design small molecules that target them are sparse. Herein, we report a general approach to score the affinity and selectivity of RNA motif–small molecule interactions identified via selection. Named High Throughput Structure–...
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| Wydane w: | ACS Cent Sci |
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| Główni autorzy: | , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Chemical Society
2017
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5364451/ https://ncbi.nlm.nih.gov/pubmed/28386598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.7b00009 |
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