CDDO-Me reveals USP7 as a novel target in ovarian cancer cells

Deubiquitinating enzyme USP7 has been involved in the pathogenesis and progression of several cancers. Targeting USP7 is becoming an attractive strategy for cancer therapy. In this study, we identified synthetic triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid (CDDO-Me...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Qin, Dongjun, Wang, Weiwei, Lei, Hu, Luo, Hao, Cai, Haiyan, Tang, Caixia, Wu, Yunzhao, Wang, Yingying, Jin, Jin, Xiao, Weilie, Wang, Tongdan, Ma, Chunmin, Xu, Hanzhang, Zhang, Jinfu, Gao, Fenghou, Wu, Ying-Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363571/
https://ncbi.nlm.nih.gov/pubmed/27780924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12801
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