Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation

SUMO-specific protease 1 (SENP1), a member of the de-SUMOylation protease family, is elevated in prostate cancer (PCa) cells and is involved in PCa pathogenesis. Momordin Ιc (Mc), a natural pentacyclic triterpenoid, inhibited SENP1 in vitro, as reflected by reduced SENP1C-induced cleavage of SUMO2-Δ...

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Udgivet i:Oncotarget
Main Authors: Wu, Jingjing, Lei, Hu, Zhang, Jinfu, Chen, Xiangyun, Tang, Caixia, Wang, Weiwei, Xu, Hanzhang, Xiao, Weilie, Gu, Wenli, Wu, Yingli
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312290/
https://ncbi.nlm.nih.gov/pubmed/27449295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10636
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