Montelukast inhibits hypoxia inducible factor-1α translation in prostate cancer cells

Through regulating the expression of hundreds of genes, hypoxia-inducible factor -1(HIF-1) plays a critical role in hypoxic adaption of cancer cells and is considered as a target for cancer therapy. Here we show that montelukast, a clinical leukotriene receptor antagonist for the treatment of asthma...

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Bibliographic Details
Published in:Cancer Biol Ther
Main Authors: Tang, Caixia, Lei, Hu, Zhang, Jinfu, Liu, Meng, Jin, Jin, Luo, Hao, Xu, Hanzhang, Wu, Yingli
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2018
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067895/
https://ncbi.nlm.nih.gov/pubmed/29708817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2018.1451279
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