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Montelukast inhibits hypoxia inducible factor-1α translation in prostate cancer cells

Through regulating the expression of hundreds of genes, hypoxia-inducible factor -1(HIF-1) plays a critical role in hypoxic adaption of cancer cells and is considered as a target for cancer therapy. Here we show that montelukast, a clinical leukotriene receptor antagonist for the treatment of asthma...

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Détails bibliographiques
Publié dans:Cancer Biol Ther
Auteurs principaux: Tang, Caixia, Lei, Hu, Zhang, Jinfu, Liu, Meng, Jin, Jin, Luo, Hao, Xu, Hanzhang, Wu, Yingli
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067895/
https://ncbi.nlm.nih.gov/pubmed/29708817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2018.1451279
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