CDDO-Me reveals USP7 as a novel target in ovarian cancer cells

Deubiquitinating enzyme USP7 has been involved in the pathogenesis and progression of several cancers. Targeting USP7 is becoming an attractive strategy for cancer therapy. In this study, we identified synthetic triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid (CDDO-Me...

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Vydáno v:Oncotarget
Hlavní autoři: Qin, Dongjun, Wang, Weiwei, Lei, Hu, Luo, Hao, Cai, Haiyan, Tang, Caixia, Wu, Yunzhao, Wang, Yingying, Jin, Jin, Xiao, Weilie, Wang, Tongdan, Ma, Chunmin, Xu, Hanzhang, Zhang, Jinfu, Gao, Fenghou, Wu, Ying-Li
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363571/
https://ncbi.nlm.nih.gov/pubmed/27780924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12801
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