Elevation of n-3/n-6 PUFAs ratio suppresses mTORC1 and prevents colorectal carcinogenesis associated with APC mutation

Although epidemiological and preclinical studies have shown the preventative effect of n-3 polyunsaturated fatty acids (PUFAs) on colorectal cancer (CRC), the underlying molecular mechanisms are not clear. In this study, we revealed that elevation of n−3/n-6 PUFAs ratio suppress the mechanistic targ...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Liu, Miao, Zhou, Ling, Zhang, Baiyu, He, Minhong, Dong, Xiaoying, Lin, Xiaojun, Jia, Chunhong, Bai, Xiaochun, Dai, Yifan, Su, Yongchun, Zou, Zhipeng, Zheng, Hang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363561/
https://ncbi.nlm.nih.gov/pubmed/27769066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12759
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