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mTORC2 promotes cell survival through c-Myc–dependent up-regulation of E2F1
Previous studies have reported that mTORC2 promotes cell survival through phosphorylating AKT and enhancing its activity. We reveal another mechanism by which mTORC2 controls apoptosis. Inactivation of mTORC2 promotes binding of CIP2A to PP2A, leading to reduced PP2A activity toward c-Myc serine 62...
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| 出版年: | J Cell Biol |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4602034/ https://ncbi.nlm.nih.gov/pubmed/26459601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201411128 |
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