mTORC2 promotes cell survival through c-Myc–dependent up-regulation of E2F1

Previous studies have reported that mTORC2 promotes cell survival through phosphorylating AKT and enhancing its activity. We reveal another mechanism by which mTORC2 controls apoptosis. Inactivation of mTORC2 promotes binding of CIP2A to PP2A, leading to reduced PP2A activity toward c-Myc serine 62...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Cell Biol
Main Authors: Zou, Zhipeng, Chen, Juan, Liu, Anling, Zhou, Xuan, Song, Qiancheng, Jia, Chunhong, Chen, Zhenguo, Lin, Jun, Yang, Cuilan, Li, Ming, Jiang, Yu, Bai, Xiaochun
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2015
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4602034/
https://ncbi.nlm.nih.gov/pubmed/26459601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201411128
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