mTORC2 promotes cell survival through c-Myc–dependent up-regulation of E2F1

Previous studies have reported that mTORC2 promotes cell survival through phosphorylating AKT and enhancing its activity. We reveal another mechanism by which mTORC2 controls apoptosis. Inactivation of mTORC2 promotes binding of CIP2A to PP2A, leading to reduced PP2A activity toward c-Myc serine 62...

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Vydáno v:J Cell Biol
Hlavní autoři: Zou, Zhipeng, Chen, Juan, Liu, Anling, Zhou, Xuan, Song, Qiancheng, Jia, Chunhong, Chen, Zhenguo, Lin, Jun, Yang, Cuilan, Li, Ming, Jiang, Yu, Bai, Xiaochun
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2015
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4602034/
https://ncbi.nlm.nih.gov/pubmed/26459601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201411128
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