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The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo

Prion diseases are fatal neurodegenerative disorders affecting several mammalian species, characterized by the accumulation of the misfolded form of the prion protein, which is followed by the induction of endoplasmic reticulum (ER) stress and the activation of the unfolded protein response (UPR). G...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Park, Kyung-Won, Eun Kim, Gyoung, Morales, Rodrigo, Moda, Fabio, Moreno-Gonzalez, Ines, Concha-Marambio, Luis, Lee, Amy S., Hetz, Claudio, Soto, Claudio
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363067/
https://ncbi.nlm.nih.gov/pubmed/28333162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44723
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