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The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo

Prion diseases are fatal neurodegenerative disorders affecting several mammalian species, characterized by the accumulation of the misfolded form of the prion protein, which is followed by the induction of endoplasmic reticulum (ER) stress and the activation of the unfolded protein response (UPR). G...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Park, Kyung-Won, Eun Kim, Gyoung, Morales, Rodrigo, Moda, Fabio, Moreno-Gonzalez, Ines, Concha-Marambio, Luis, Lee, Amy S., Hetz, Claudio, Soto, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363067/
https://ncbi.nlm.nih.gov/pubmed/28333162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44723
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